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Posts Tagged ‘Cancer’

To call what the Hyde family has been through a “parent’s worst nightmare” sounds like a horrible cliche. But, it’s hard to imagine what else you could call it. Their two-year old son Cash was diagnosed last year with a stage 4 brain tumor; he nearly died more times than they can count. He was miserable from the chemotherapy coursing through his body. Until his dad made a controversial decision to give cannabis to his young son. KXLY 4′s Melissa Luck reports.

One of the great ironies in the debate over marijuana’s medical applications is that the drug may prove to be vastly more useful than many marijuana activists even realize. As the US government continues to block medical marijuana research, scientists around the world are discovering new and exciting possibilities: Investigators at Bar-Ilan University in Israel report that the administration of THC significantly affects the viability of GBM cells. Glioblastoma multiforme, the most aggressive form of glioma (brain cancer), strikes some 7000 Americans annually, and generally results in death within one to two years following diagnosis. “THC [is] an essential mediator of cannabinoid antitumoral action,” investigators concluded. read the full text here: stopthedrugwar.org

San Francisco Medical Marijuana Stops Spread of Breast Cancer – NBC NEWS Marianne Favro/KNTV Reporting EXCERPTED FROM PUBMED: Cannabidiol enhances the inhibitory effects of Delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival: The cannabinoid 1 (CB(1)) and cannabinoid 2 (CB(2)) receptor agonist Delta(9)-tetrahydrocannabinol (THC) has been shown to be a broad-range inhibitor of cancer in culture and in vivo, and is currently being used in a clinical trial for the treatment of glioblastoma. It has been suggested that other plant-derived cannabinoids, which do not interact efficiently with CB(1) and CB(2) receptors, can modulate the actions of Delta(9)-THC. There are conflicting reports, however, as to what extent other cannabinoids can modulate Delta(9)-THC activity, and most importantly, it is not clear whether other cannabinoid compounds can either potentiate or inhibit the actions of Delta(9)-THC. We therefore tested cannabidiol, the second most abundant plant-derived cannabinoid, in combination with Delta(9)-THC. In the U251 and SF126 glioblastoma cell lines, Delta(9)-THC and cannabidiol acted synergistically to inhibit cell proliferation. The treatment of glioblastoma cells with both compounds led to significant modulations of the cell cycle and induction of reactive oxygen species and apoptosis as well as specific modulations of extracellular signal-regulated kinase and caspase activities. These specific changes were not observed with …